Clinical Study shows high effectiveness of Go-Less®

A recently published clinical study shows that Go-Less® is an effective natural ingredient that helps to improve the quality of life in women by reducing the symptoms of overactive bladder.

A placebo-controlled, randomized clinical trial conducted by Shim, B., et al., at Ewha Woman’s University, Seoul, South Korea, and supported by Frutarom Health BU, Switzerland, was published in April, 2014[i]. Go-Less, developed and marketed by Frutarom Health BU, is a proprietary blend of a water-soluble pumpkin seed extract (EFLA®940) and the soy germ extract, SoyLife®. Separately, both ingredients have been successfully marketed for many years. Now, combined into the proprietary blend Go-Less, they show a combined effect of the constituents from pumpkin seeds and the hormone-balancing action of soy germ isoflavones.

The study included 120 women suffering from overactive bladder-related voiding dysfunction. The women, aged between 35 and 70 years, took 500 mg of Go-Less or matching placebo tablets (60 placebo/60 test group) twice a day during a 12-week period. The average frequency of nocturia was measured, showing, a notable decrease of around 30%.

After week 12, a significant decrease of the daily average frequency of urination was reported. More critically, there was a substantial decrease in the average urgency score in the Go-Less group. “Urgency is one of the biggest inconvenience conditions, in practice, for people suffering from overactive bladder,” says Patricia Maureira, Product Manager of LifeLine® at Frutarom Health. “It can be frustrating and constraining, and lead affected people to feel insecure.”

The functionality of Go-Less was also confirmed by a survey on the subjective satisfaction of the participants, as conducted at the end of the trial period. More than 90% of the subjects in the Go-Less group found the product helpful and answered affirmatively when asked if they would like to continue taking the study product. This compares to about 50% in the placebo group.

“The market for urinary health remedies in adults is fast growing, especially in Western Europe and the U.S. where Baby Boomers and younger sufferers are seeking natural and effective remedies to match their healthy lifestyle,” adds Maureira “The result of this study confirms that Go-Less is an effective, natural aid for addressing overactive bladder and urinary incontinency. It therefore is a valuable ingredient, with highly attractive positioning opportunities in the growing market for urinary health-supporting products.”

Go-Less opens a broad range of application possibilities, offering manufacturers of food supplements and nutraceuticals a unique ingredient to benefit from the growing market of urinary health. It can be used in capsules, tablets, powdered beverages, bladder support formulations, women’s health and prostate health formulations.

Frutarom is one of the leading flavor and fine ingredients house ranked among the ten leading companies in the global market. Fulfilling its commitment to become the preferred partner for tasty and healthy success, Frutarom provides advanced solutions for the food & beverage, nutraceutical, pharmaceutical and cosmetic industries.



[i] Shim, B., et al., A randomized double-blind placebo-controlled clinical trial of a product containing pumpkin seed extract and soy germ extract to improve overactive bladder-related voiding dysfunction and quality of life. Journal of Functional Foods, 2014, 8(0): p. 111-117